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Dr. Grünberg's Movement Medicine

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Dr. Grünberg's Movement Medicine
Myokines: Understanding the Secret Signaling Molecules of Muscles

Myokines - Muscle health - physical activity - Signaling substances - Diabetes

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Dr. med. Lisa Grünberg
Dr. med. Lisa Grünberg

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HEALTH ESSENTIALS

Imagine a future where a simple walk around the block is enough not only to improve your heart health but also your memory and overall well-being. This vision may soon become a reality thanks to the fascinating world of Myokines. These secret messengers are the key to why physical activity has so many positive effects on our bodies. But what exactly are Myokines, and why are they so significant for our health?

Myokines are proteins or peptides released by muscles during contraction. They serve as communication signals between our muscles and other organs and systems in the body. These messengers play a vital role in regulating metabolic processes, tissue growth and repair, and even modulating our immune response. The discovery of myokines has transformed our view of muscle cells from mere powerhouses to significant hormonal centers.

Myokines help improve many aspects of human health. Regular physical activity increases the production of these signaling molecules, which are associated with numerous health benefits. For example, certain myokines can enhance Insulin sensitivity, thereby reducing the risk of Type-2 Diabetes [1]. Additional benefits include reducing inflammation in the body and promoting cardiovascular health [2].

Studies have shown that a lack of physical activity significantly reduces the release and effectiveness of myokines. One study examined the impact of short-term immobilization on the release of myokines and found an increase in intramyocellular lipids, which deteriorate Insulin Sensitivity in muscles [3]. The quality of this study supports the conclusion that even short periods of inactivity can be detrimental.

Another investigation found that both endurance and strength training release a variety of myokine signaling molecules that lead to systemic adaptations extending well beyond muscle health [4]. These studies use robust study designs and a sufficient sample size, making their claims reliable, although further research is needed to fully understand the mechanisms involved.

To fully harness the benefits of myokines, it is important to be regularly physically active. Incorporate various forms of exercise into your daily routine: both endurance activities such as running or cycling and strength training could help boost the production of these valuable signaling molecules [5]. Additionally, try to avoid prolonged sitting to support the continuous release of myokines and optimize your Insulin Sensitivity [3].

Myokines are essential players in understanding and leveraging the far-reaching benefits of physical activity for our health. Through an active lifestyle and targeted exercises, we can stimulate the production of these natural signaling molecules. Take the leap into a healthier life by moving regularly and reaping the amazing benefits of myokines for your health.

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This harms

  • Lack of physical activity, which leads to the underproduction of myokines [1] [2]
  • Excessive sedentary behavior that inhibits the release of myokines [3]
  • Lack of knowledge about the benefits of targeted exercises for the increase of specific myokines [5] [4] [6]

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